One of the most useful books I've ever read period. I've been suffering from a "mysterious illness" where life has been drained out of me leaving me severely stressed, fatigued, lifeless ... with no obvious medical diagnosis. Doctors consulted thought I was either crazy or mental. Nothing seemed to help. Conventional medical tests didn't reveal anything useful. Anti-depressants didn't do much. ... I was alone in my fight to recover energy, savage a struggling career, and nurture a young family. The negative impacts on life, career, and family have been indescribable. Refusing to give up on hope, I researched as much as energy and time would allow (read very day/night), I came across this book through other books and thyroid forums' postings. After about 2 months of implementing the author's suggestions, I'm happy to report that my latest 24-hr saliva cortisol tests came back near optimal and even HIGH at night. Astounding. Similar tests done 7 months ago showed results consistent with "Adrenal Fatigue phase 3" corresponding with my constantly lousy feelings. With my holistic MD's help in prescribing NDT and T3 together with the instructions and tips contained in this handbook, my cortisol levels and energy have recovered in conjunction with my MTHFR protocol. I've been given a second chance at feeling better and life. Though recovery is on-going, I can't thank the author enough. Mr. Robinson, your CT3M discovery has done me a great service. I'm sure there are countless others like me. In fact, I bought a copy of this handbook as a gift to my MD who called me a few weeks later to tell me that she'd enjoyed the book and is interested in talking about it at next office visit. That's wonderful!