Empower your resilience to physical and emotional stress by supporting HPA axis balance. Experience Relief with the Only Standardized Liquid of Licorice Root Extract The Licorice Root Extract Advantage BioMatrix Licorice Root Extract is the only supplement of its kind that states exactly how much of the active ingredient – glycyrrhizin – is in each drop. Other brands may not even know how much they have in their product and suggest high doses which could be dangerous or counterproductive. Our standardized strength per drop is 0.84 mg of glycyrrhizin. This allows you to confidently manage your dosing one drop at a time with utmost precision. Our liquid form is highly bioavailable due to its oral and lymphatic absorption. Precision dosing means your product will last longer and save you money versus cheaper products. What is Glycyrrhizin? Glycyrrhizin blocks an enzyme called 11-beta-hydroxysteroid dehydrogenase from downgrading cortisol (which lowers the cortisol reserves you need for health). BioMatrix’ LRE possesses a potent concentration of glycyrrhizin to help preserve your naturally produced cortisol. It is not to be confused with deglycyrrhizinated licorice, which is relevant to digestive concerns. HPA Axis Benefits for Everyday Use Using Licorice Root Extract to raise cortisol is one of the most common methods clinicians use to improve their patients’ energy and mood. It forms the cornerstone of therapies which often include other hormones, such as pregnenolone, DHEA, and progesterone. Under stress, your glands secrete cortisol. This hormone is part of your body’s natural stress response, the HPA axis. The HPA axis triggers reactions that influence metabolic actions that play roles in your overall health. Even when cortisol levels are low, and glands fatigued, the HPA axis keeps working to produce more cortisol, contributing to a vicious cycle of fatigue and frequent illness. Purpose and impact in every drop. Licorice Root Extract Yielding Precision-Dosed Glycyrrhizin for High Absorption Glycyrrhizin (from Licorice Root Extract) – A triterpene glycoside (a type of beneficial plant metabolite), that is extracted from the root of the licorice plant, Glycyrrhiza glabra. The root contains a mixture of potassium, calcium, and magnesium salts of qlycyrrhizic acid (aka glycyrrhizin). It is effective in therapies intended to increase cortisol production. Glycerin – Preserves the formula’s integrity and potency, through its protective properties. Sourced from RSPO sustainable palm oil. About the Formula Glycyrrhizin per Drop 0.84 mg Drops per bottle ~1200 Suggested Use Supplements that can impact cortisol levels should be taken low and slow to start. As a general recommendation, take 8-10 drops 1-2 times daily or as recommended by your health care professional. Start with a lower amount if you are uncertain. Ingredients Licorice Root Extract (from Glycyrrhiza glabra, yielding 0.84 mg/drop of Glycyrrhizin) – 10.5 mg. Other Ingredients: Glycerin (from palm oil), purified water. Allergen Info No known allergens Formulated to be free of: Egg, Dairy, Shellfish/Fish, Tree Nuts/Peanuts, Soy, Gluten, Bromelain, Corn, Artificial Colors, Artificial Flavors, Artificial Preservatives, Sodium, Sugar, Rice. How do I take this product? Our licorice root extract liquid is designed to be taken orally. Keep the product in your mouth as long as possible to optimize absorption. How does the glycyrrhizin ingredient work? The glycyrrhizin compounds block 11-β-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive form. What is the glycerin derived from? Certified Sustainable Palm Oil (CSPO) - refined hard fractionated of palm oil. An ideal carrier to keep the formula's suspension intact, in tandem with the purified water. When should I take it? This product can be taken before or after meals. It is typically taken in the morning (6-8 am) and/or midday (12-2 pm). To dial in specific dosage timing, you may benefit from taking a cortisol lab test to see when cortisol levels are low. BioMatrix Hormone Supplements - Purpose and Features Compared Licorice Root Extract DHEA Pregnenolone What does it do? Contains glycyrrhizin to help increase low cortisol levels without stimulation. What does it do? Increases levels of DHEA to help balance healthy cortisol and sex hormones. What does it do? Pregnenolone is the master hormone that converts to all other hormones. For HPA fatigue therapy? Yes - when cortisol levels are too low. For HPA fatigue therapy? Yes - Except in cases of known high DHEA levels. For HPA fatigue therapy? Yes - Appropriate for all stages of therapy and for maintenance.