My 20lb terrier/spaniel mix had been sick since May (3 months) and getting worse. She had several blood panels, and the ACTH test confirmed mild Cushing's. Switching her from hard food to fresh (Petsmrt) resulted in her ALP going from 625 to 228. Still high, but much better. It solved her drinking issues, 3x normal, and pottying accidents. In the last month her back legs have gotten worse. She no longer wants to go on walks. I have to carry her to the lawn to do her business. She is blind, another related side effect, but can go up and down stairs. The specialty vet recommended 20mgs of Trilostane (Vetoril) daily. They warned that it was hard on dogs and they were right. This made her noticably worse and I immediately discontinued it. Another vet suggested Melatonin. One pill made her restless and worse. Glucosamine/Chondroitin pill 1x day didn't do anything for her. Last night, I added the Adrenal Harmony Gold drops to her food. (She has a voracious appetite, a side effect of Cushing's.) This morning, I came downstairs and there she was, waiting for me by the front door to go potty! I could not believe it. She acts like she feels like a million bucks! This is after just one dose (and actually half of the correct dose, more on that later. I'm just amazed since I've spent thousands of dollars on tests, stress on her and months with no improvement. No vet even mentioned this product. If your dog has Cushing's or the symptoms, I would highly recommend trying this. The company offers a money back guarantee. My dog has almost all of these, except for the skin issues.Cushing's symptoms: Your dog is:Thirstier than usualSeems hungrierPees more often. Housebroken dogs may have indoor accidents.Loses hair or it is slow to growGets a pot bellyHas thinning skinSeems very tired and inactivePants a lotGets skin infectionsSwitching food plus this supplement was expensive, but so worth it. Thank you to the other reviewers. This is my honest review, I don't work for any related company and didn't received any discounts.-----------------------------------------------Update: It's been a couple weeks and I'm giving her the suggested dose split between meals - on her fresh food. It says bacon flavored and she loves the fresh food. Pup is doing well and still goes out on her own to the restroom. Her leg weakness is improving. I read it can take a long time for that to resolve. Fresh food is a game changers. It solved her drinking/pottying issues and improved her liver values drastically - that is the only change I made during that time period. When I tried reintroducing dry food (I tried 3-4 high end foods), even as part of her diet, her demeanor was markedly worse.-----------------------------------------------Update 2: My dog had diarrhea for several months. My vet noticed the bottle said, may be a GI irritant. I immediately discontinued it and she placed her on an antibiotic. I feel terrible for not noticing this warning. It's been a week since I've made this change and her diarrhea is improving. From her sickest until now, my dog is much improved - happy, no more moaning like she used to, her appetite is great, her leg strength is back and she climbs up and down stairs again. The vet ssuggested a mild diet since her second round of antibiotics (white rice, eggs, chicken and/or turkey). Find a good vet and trust your gut to do what you think is best for your dog's situation. There are different variations of Cushing's, as well. This may not work for all dogs. The disease is more prevalent in certain breeds.------------------------------------------------Update 3:After a week off of Adrenal Gold, she was deteriorating - low energy, hind legs issues and just not her peppy self. I realized I'd been dosing her half of what the bottle recommended, ugh! 10 drops per day than 2x per day. So, back on Adrenal Gold again and I am experimenting with her food to get the right combination that won't cause diarrhea. A high protein, low fat diet is recommended - I now make her food. Please tell your very if this works for your dog so other dogs will be saved from a premature death----------------------------------------------It's been one year since Bella started this medicine (+ fresh food) and she is doing great. OthShe can go on short walks and is her tail wagging, happy self. I buy this from Amazon or direct from the manufacturer. The dosage on the bottle is appropriate. I amake her food as follows: I chop/combine the following cooked 9 ingredients: 2 lbs ground turkey, 1 dozen free range eggs, 1 bag frozen organic spinach, chopped green beans, cubed organic sweet potatoes, ~ 1/3 cup olive oil (I use California brand), large container organic plain greek yogurt, apple and instant organic cooked steel cut oatmeal. I make batches for several weeks and freeze what I don't use within 5 days. I give her one drop a day of a product called Biosil for hair growth.--------------------------------------------11/11/16Bella is still doing great - 95% of what she was pre-illness. People who haven't seen her in awhile remark at how well she looks and acts. She loves short walks and has a voracious appetite like always. I give her people food for snacks - corn chips, strawberries, raspberries, small pieces of frozen cooked meat, etc. as my vet recommended. Adrenal Harmony Gold 2x a day with her food. This product has given me my dog back and I'm so grateful ?. There are hundreds of reviews on the retailer's direct website, too.----------------------------------------5/12/18 UpdateMy dog is still doing well on the same protocol. Last batch I put the turkey and eggs in a crock pot, mashed it up with my hands, added steel cut oats (maybe a cup?) a bag each of frozen organic sweet potatoes, squash and spinach (all from Walmart) and cooked it in a crock pot on high for 3 hours, added the chopped organic apples, olive oil and yogurt.5/30/19 UpdateGirlfriend is still kicking! My biggest struggle this past year is getting her to eat. I’ve experimented *a lot* – an expert told me oats aren’t good for dogs and sprouted buckwheat is a good alternative. I figured out she gets bored with her food and has trouble smelling it I alternate between different brands of fresh food usually delivery. I bought a feeder with a cold pack in the bottom and sections that rotate, so she is never without food. She definitely gets “hangry” or anxious when she is hungry. Sometimes it’s just water she needs and I have to place her in front of her water bowl so she finds it. For treats she gets Nature Valley Granola bar (crunchy, broken up) or fast food plain cheeseburger. She also wears washable dog diapers I got on Amazon.3/23/20It's been almost 5 years. 3 months ago, she started having bloody diarrhea that would not resolve. I realized that she had all of the symptoms of Addison's (the opposite of Cushing's), took her off her medicine and took her to the vet. He prescribed Reglan, Sucraflate and Metronidazole. This really helped get her stools close to normal. After 2 weeks being off Adrenal Harmony Gold, the blood test showed her ALP high 200s, close to where she was when she was originally on the medication, nothing else very serious. If your dog is having intestinal issues, consider stopping this medication. She is blind/deaf, spins in circles, sleeps a lot, but is still able to find her food, water and walk around outside.12/5/20 Bella passed over to the Rainbow Bridge on November 6th. 5 years after we thought we'd have to put her to sleep. In retrospect, her spinning/restless behavior was often because she was hungry. She couldn't smell well likely because of years of blindness and running into walls with her little nose. She wasn't on this med since the last update. Thanks for all of the 'likes', it made the process all worth it. None of the many vets ever suggested this medicine. Please tell your vets and friends, so more dogs can be spared the pain of this illness. Feed your dog real food! There are many variations of Cushing's, don't give up on finding what works for your dog. My true and honest experience after much research and $$$. ??11/1/21Ashwaganda is a main ingredient in this medicine. I personally tried it to keep me from waking up at night. Even at a low dose, it made me anxious, anxious enough that I won't take it. This is not uncommon. Bella was very anxious, especially towards the end of her life. I do wish I had scaled back on this medicine at times. That and keep an eye on stomach upset, as well. It's a balancing act. Research and do what works for your fur baby.